Chinese scientists first card Zhai card virus led directly to microcephaly
China News Agency, Beijing, May 12 (Xinhua Zhang Su) Zhai spreading virus has spread all over the world, classified by the World Health Organization as "a public health emergency of international concern". Chinese scientists for the first time confirmed that Zhai card virus directly leads to microcephaly, relevant papers published on 12th at the internationally renowned journal cell stem cell (CellStemCell).
The study by the Institute of genetics and developmental biology, Chinese Academy of Sciences Research team Xu Zhiheng, and Academy of military medical Sciences Institute of microbial epidemics Qin Chengfeng team collaboration. They established a village for the first time the virus animal model of microcephaly and confirmed that Zhai card virus can directly cause occur microcephaly.
According to statistics, the March 2015 to March 2016, Brazil has more than 6,500 employees baby was diagnosed with microcephaly, 20 times higher compared with previous years, and most of these mothers of children with Zhai card virus infected. Microcephaly is a rare disease, refers to abnormal fetal or infant brain development in the womb, lead to much smaller heads, which there may be mental development in children with significant delay, epilepsy, movement disorders, language disorders and symptoms such as abnormal behavior, in the United States about two out of 10,000 to twelve out of 10,000.
"Zhai card virus and discussed before is to look at the relationship between the clinical manifestation of microcephaly, scientific evidence is not sufficient. "Xu Zhiheng said in an interview, by direct injection of low concentration in pregnant rats with a fibre needle Zhai card virus, mouse embryonic brain development.
Studies have shown that Zhai card virus quickly copied in the embryonic brain, "viruses in only 3 days increased by more than 300 times" "infection and proliferation and differentiation of neural stem cells and its exceptions, also killed a large number of neurons, leading to cortical thinning, and microcephaly.
Xu Zhiheng said by genome-wide expression profiling and found numerous immune, microcephaly, Zhai card potential receptors and apoptosis-related gene abnormality, thus mastering "direct evidence".
"This is a complete work done right here in China. "Qin Chengfeng said their domestic first virus samples were extracted from the input cases patients who completed the study. Two laboratory of interdisciplinary collaboration, better scientific results in a short time.
Xu Zhiheng said that drugs and vaccines can be made with this model the filter, provides help for village card virus infection prevention and treatment. He told news agency reporters, will also work with foreign laboratories for basic research, such as individually in the neural stem cell cultured in vitro and in vivo studies.
Author: Zhang Su
(Editors: Liu Cheng UN649)
2016-05-12 12:45:20
China News Network

中国科学家首证寨卡病毒感染直接导致小头畸形
中新社北京5月12日电  (记者 张素)寨卡病毒已在全球范围内播散蔓延，被国际卫生组织定为“国际关注的突发公共卫生事件”。中国科学家首次证实寨卡病毒感染直接导致小头畸形，相关论文12日发表在国际知名期刊《细胞—干细胞》(CellStemCell)。

　　该项研究由中国科学院遗传与发育生物学研究所许执恒研究团队，与军事医学科学院微生物流行病研究所秦成峰研究团队合作完成。他们首次建立了寨卡病毒小头畸形动物模型，并证实寨卡病毒可以直接导致小头畸形的发生。

　　据统计，2015年3月至2016年3月，巴西有6500余名婴儿被诊断患有小头畸形，与往年相比高出20倍，而这些患儿的母亲大多感染了寨卡病毒。小头畸形是一种罕见疾病，是指胎儿在子宫内或婴儿期大脑发育异常，导致头部明显变小，这些患儿有可能出现智力发育显著迟缓、癫痫、运动障碍、语言障碍及行为异常等症状，在美国发病率约为万分之二到万分之十二。

　　“以前探讨寨卡病毒与小头畸形的关系是看临床表现，科学依据并不充分。”许执恒在接受记者采访时说，通过用纤维针向孕鼠直接注射低浓度寨卡病毒，观察小鼠胚胎的大脑发育情况。

　　研究表明，寨卡病毒在胚胎脑中快速复制，“仅3天病毒量就增加了300多倍””，并感染神经干细胞并造成其增殖与分化异常，还使大量神经元死亡，导致大脑皮层变薄及小头畸形。

　　许执恒说，通过全基因组表达谱分析，最终发现大量与免疫、小头畸形、寨卡病毒的潜在受体及细胞凋亡相关的基因出现明显异常，由此掌握了“直接证据”。

　　“这是一项完全在中国本土完成的工作。”秦成峰对记者说，他们在国内首先从输入性病例患者身上提取了病毒样本，完成了这项研究。而两个实验室的跨学科合作，使在短时间内产出较好的科学成果。

　　许执恒表示，利用该模型可以进行药物及疫苗筛选，为寨卡病毒感染的预防和治疗提供帮助。他对中新社记者表示，也将与国外实验室合作进行基础研究，比如分别在体内和体外培养神经干细胞中进行相关研究。

　　作者：张素
(责任编辑：刘盛钱 UN649)
2016-05-12 12:45:20
中国新闻网