China's longest-frozen "ice babies" born cryogenic sleep for 18 years _ | | embryos frozen thin news
Original title: China's longest-frozen "ice baby" is born
Embryologist/interviews for out of frozen embryos in liquid nitrogen tanksMorning news reporter Chen Li
-196 ℃, in 1998 by the frozen embryos, wake up? On June 27, 45 year old Huang Chiung-piao (a pseudonym) in Jiangsu successfully gave birth to a baby girl, baby weight 3300 g, all normal body. Yesterday, Fudan University subsidiary obstetrics and Gynecology hospital revealed, dang this China most "anti-frozen" baby also is a gold embryos of when, had in Fudan University subsidiary obstetrics and Gynecology hospital Shanghai set love genetic and not Yu clinic Center quiet to "sleeping" has 18 years, until last year November early, was Shanghai set love genetic and not Yu clinic Center Chen doctor "wake", and success transplant to Huang Chiung-piao of uterine within.
A comprehensive two-child policy after landing, exponential growth of assisted reproduction clinic, the hospital gave the remaining frozen embryos in hopes of many mothers having a second child. For women who plan to use frozen embryos to bear, embryologist, they point out: "the needs of their endometrial thickness, health overhaul such as cesarean section scar, suitability to bear at the same time, age is also critical, early childbearing. ”
Overcome numerous difficulties to successful pregnancy
In early 2015, when Chen said doctors saw Huang Chiung-piao's medical record number-"1998-01XX" heart was stunned: "this Centre was established in 1998 originally ' original fans ' Ah! Afterlife of estimate is in line with the two-child policy to have two children. ”
Detailed history before that, the couple have blocked fallopian tubes in 1998 at the Centre for assisted reproductive treatment, one fresh embryo transfer with two frozen embryo transfer failed, Huang Chiung-piao his confidence: "was that busy, and we want to talk about it, and so on. "This class is for 18 years. An acquaintance of twins in the treatment of Chen's message to Huang Chiung-piao hope: "I still have the frozen embryos in the set to love, to give it a try! ”
Chen discovered that transplanted three times before Huang Chiung-piao hydrosalpinx and thin endometrial issue, she once again and in the ultrasound room Yang Yuezhou checked Huang Chiung-piao, Director of the uterus, ovaries and fallopian tubes, inner membrane is still very thin, tubal serious water, also associated with uterine fibroids. Chen said doctors and suggest removal of fallopian tubes at the same time, she also fears that embryos frozen for 18 years, if recovery stops growing, fallopian tubes are not white?
This time, Huang Chiung-piao was adamant: "18 years ago doctors advised me to remove, I hesitated, maybe that's three reasons for graft failure. "Obstetrics and Gynecology hospital affiliated to Fudan University FEM physician surgeon, laparoscopic resection of a large amount of water tubes, remove fibroids while using a Hysteroscopy to remove uterine problems. After successful surgery, Huang Chiung-piao began a year of frozen embryo transfer cycle of recovery, in Chen's individualized treatment plan and b-rooms, the embryo laboratory support following the successful transplant.
Two weeks later, Huang Chiung-piao back Center HCG blood values, when she heard the news of their pregnancy, and hold Chen.
Period, there is no regulatory
According to the Central Sun Xiaoxi, Vice President recalls: "18 years ago, embryo vitrification technology is not for use in assisted reproduction, China, most frozen embryos using programmed slow freezing techniques, embryo survival after thawing was about 80%, when the average pregnancy success rate was only about 30%. "Now, the embryo vitrification technology is more mature, the Center last year after thawing of frozen embryo transplant rate is about 99.5% after transplantation, the pregnancy rate is about 43.4%.
The shelf life of frozen embryos, at present, yet relevant laws and regulations. Shelf life frozen embryos in each country in the world in 5-10, the Shanghai Municipal Health Bureau released in 2013 on the human assisted reproductive technology services in notice of project quality control it is recommended due to long-term Cryopreserved embryos could pose a reproductive risk and socio-ethical issues, according to the internationally accepted principle of clinical use of frozen embryos generally kept within 5 years. At the operational level, hospitals have frozen embryos being very careful set love centres embryonic Sun Yijuan, Lab Director said: "as long as the patient does not sign the informed consent to give up frozen embryos, even if they fail to save costs, or even lost, we will help them continue their frozen embryos. ”
Responsible editor: Qiao Leihua SN098
Article keywords:Embryo freezing with a thin
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中国冷冻最久“冰宝宝”出生 低温下沉睡18年|胚胎|冷冻薄薄_新闻资讯
原标题：中国冷冻最久“冰宝宝”出生
胚胎学家正从液氮罐里取出冷冻胚胎/采访对象供图 晨报记者 陈里予
-196℃，1998年被冷冻的胚胎，被唤醒？6月27日，45岁的黄琼（化名）于江苏顺利诞下一名女婴，婴儿重3300克，身体指标一切正常。昨天，复旦大学附属妇产科医院透露，当这名中国最“抗冻”宝宝还是一枚胚胎的时候，曾在复旦大学附属妇产科医院上海集爱遗传与不育诊疗中心安静地“沉睡”了18年，直到去年11月初，被上海集爱遗传与不育诊疗中心陈华医生“唤醒”，并成功移植到黄琼的子宫内。
全面二孩政策落地之后，辅助生殖中心门诊量激增，医院中剩余的冷冻胚胎给了许多妈妈生二胎的希望。对于打算用冷冻胚胎再生育的女性，胚胎学家们指出：“需要对自身子宫内膜厚度、剖宫产疤痕等身体状况做全面检查，看是否适合再生育，同时，年龄也很关键，建议尽早生育。”
克服重重困难顺利怀孕
2015年初，当陈华医生看到黄琼的病历号——“1998-01XX”时心里一怔：“这可是中心1998年成立最初的‘元老级粉丝’啊！估计是符合二孩政策来生二胎的。”
详细询问病史后才得知，该夫妇曾因输卵管堵塞于1998年在中心接受了辅助生殖治疗，一次新鲜胚胎移植与两次冷冻胚胎移植失败后，黄琼没了信心：“加上当时工作繁忙，我们想等等再说吧。”这一等就是18年。一位熟人在陈华的治疗下喜得双胞胎的消息给了黄琼希望：“我还有冻胚在集爱呢，再来试试吧！”
陈华发现，黄琼之前三次移植都存在输卵管积水和子宫内膜薄的问题，她再次和B超室杨岳州主任检查了黄琼的子宫、卵巢及输卵管情况，内膜依旧很薄，输卵管严重积水，还伴有子宫肌瘤。陈华医生给出了切除输卵管的建议，与此同时，她也在担忧：胚胎冷冻了18年，万一复苏之后停止生长，输卵管不是白切了？
这一次，黄琼倒是很坚决：“18年前医生建议我切除，我就犹豫不决，也许这就是三次移植失败的原因。”复旦大学附属妇产科医院陈晓军主任医师主刀，在腹腔镜下切除了大量积水的输卵管，剔除了子宫肌瘤，同时用宫腔镜排除了宫腔问题。手术成功后，黄琼开始了近一年的冷冻胚胎复苏移植周期，在陈华的个性化治疗方案与B超室、胚胎实验室的积极配合下顺利移植。
两周后，黄琼回到中心检测HCG血值，当她听到自己怀孕的消息时，紧紧地抱住了陈华。
保存期限尚无相应法规
据该中心孙晓溪副院长回忆：“18年前，胚胎玻璃化冷冻技术还未运用于中国辅助生殖领域，胚胎冷冻大多采用程序化慢冻技术，胚胎解冻后存活率约为80%，当时的妊娠成功率平均只有30%左右。”如今，胚胎玻璃化冷冻技术愈发成熟，去年该中心冷冻胚胎解冻后移植率约为99.5%，移植后临床妊娠率约为43.4%。
至于冷冻胚胎的保存期限，目前国内尚未出台相应的法律法规。一般国际上各个国家冷冻胚胎保存期限在5-10年，上海市卫生局于2013年发布的《关于做好本市人类辅助生殖技术服务项目质量控制的通知》中则建议：由于长期冻存胚胎可能带来生育风险以及社会伦理问题，按国际通行原则冻存胚胎临床使用时间一般控制在5年之内。在实际操作层面，医院对于冷冻胚胎的处理慎之又慎，集爱中心胚胎实验室主任孙贻娟称：“只要患者没有签署《放弃冷冻胚胎知情同意书》，就算他们逾期不交保存费，甚至失联，我们也会帮助他们继续冷冻胚胎。”
责任编辑：乔雷华 SN098
文章关键词： 胚胎 冷冻薄薄
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