Eliminate the "fear" shadow, Chinese scientists find new ideas-trauma memories-IT information
A scream of terror, a painful memory, a terrible disaster ... ... Fear memories and perhaps a lot of people are left or dark or light shade. How to let the memory fade, how to treat pain of trauma? Recently, Chinese scientists for the first time revealed the fear memory information of important neural pathway, for the treatment of anxiety disorders and post-traumatic stress disorder provides a new way of thinking, the results, published in nature neuroscience journal.
Animals and many fear memory stems from learned. Famous Pavlovian experiment proved that as long as a sound connected with fear, again, animals would fall back into panic.
Previously, scientists believe that this is due to the fear of information will flow from the brain's auditory cortex hippocampus amygdala on the end of, which controls movement, a fear response. However, when browsing joined Atlas of the brain of mice, by the Shanghai life science Institute of neural Pu Mu-ming group researcher Yang Yang and PhD student Liu Danqian found that this process is "irreversible", lateral amygdaloid nucleus can also be cast back to the auditory cortex, and when this project is inhibition, fear in mice will be greatly reduced.
"It shows that as long as we are able to inhibit amygdala projection to auditory cortex neural circuits, mice are not afraid to let it sound of fear. If we can find the pathways in the brain, it can regulate this pathway, reducing anxiety and post traumatic stress disorders and other diseases. "Yang Yang said.
Pu Muming said that basic research findings could provide new clues for the treatment of brain diseases. Drug treatment of disease, the results are unsatisfactory, the future, physiological, physical stimulation and intervention may be able to achieve better results.
消除“恐惧记忆”阴影，中国科学家找到治疗创伤新思路 - 记忆 - IT资讯
一阵恐怖的尖叫、一段痛苦的回忆、一场惨烈的灾难……恐惧记忆也许在很多人心里都留下了或深或浅的阴影。如何让记忆淡忘，如何治疗疼痛的创伤？近日，中国科学家首次揭示了大脑记忆恐惧信息的重要神经通路，为治疗焦虑症和创伤后应激障碍提供了新的思路，该成果发表在《自然·神经科学》上。
动物对于恐惧的记忆很多源自后天习得。著名的巴甫洛夫条件反射实验证明，只要一种声音与恐惧相连，再次听到，动物就会重新陷入惊恐。
此前，科学家认为，这是由于恐惧的信息会从大脑的听觉皮层流向海马末端的侧杏仁核，进而控制运动区域，产生恐惧反应。然而，在浏览小鼠大脑联接图谱的时候，中科院上海生科院神经所蒲慕明课题组的副研究员杨扬和博士生刘丹倩发现，这一过程其实是“可逆的”，侧杏仁核也可以投射回听觉皮层，并且当这个投射被抑制时，小鼠的恐惧反应就会大大降低。
“它说明，只要我们能够抑制从侧杏仁核投射回听觉皮层的神经回路，小鼠就不会害怕此前让它恐惧的声音了。假如我们也能在人脑中找到对应的通路，就可能通过调节这个通路，减轻焦虑症和创伤后应激障碍等疾病。”杨扬说。
蒲慕明表示，这一基础研究的发现可以为脑疾病的治疗提供新的线索。目前药物治疗脑疾病效果并不理想，未来，生理、物理刺激和干预或许能够取得更好的效果。