National gene bank operations in China 5,000 years ago, Mammoths may be resurrected mammoth | | national gene pool _ | Shenzhen news
Mammoth sculpture is particularly striking in the national gene pool.
Hall has on display a variety of animal specimens.
Shenzhen within the national gene pool.
Machine room. Its stock if a person 24 hours a day, watching movies, to see 100,000 years.

Following the United States National Center for biotechnology information (NCBI), the European bioinformatics Institute (EBI), Japan DNA databases (DDBJ), fourth national gene pool-the national gene bank yesterday officially operating in Shenzhen. It is China's first and only a national gene bank, relative to the global gene pool for three, the national gene pool the size of sample storage, storage volume and the amount of data that can be accessed is the world's largest. Here, after decoding the genes to reprogram, reading to writing, synthesis and editing, or extinct species can be resurrected. Future, there will be a platform for popular science, in which there will be more public, dialogue of science.

　　Scale storage of samples over 10 million

National gene bank covers an area of over 50,000 square meters, total construction area of 116,000 square meters, has been put into use for the first area of 47,500 square meters. Construction of the phase II and phase III will be. China has this "Noah's Ark", carrying a human and other genetic samples and code.

New Express Reporter, took five years to prepare, national gene bank in the storage of biological samples and resources, genetic sequencing, gene synthesis, gene editing, database construction and industrial application of, a number of leading indicators at the international level. It is the largest gene banks around the world, in which the sample has been storing samples of more than 10 million copies of digital platform for an annual output of more than 5Pb of data; protect and preserve the living library the world about 300,000 species of plants, millions of animals, millions of microbes living resources.

　　Advantages for data development using more as

The national gene bank in Shenzhen Dapeng area is the United States National Center for biotechnology information (NCBI), the European bioinformatics Institute (EBI), Japan DNA databases (DDBJ) after the fourth national gene pool. First three gene pool is more to save the data, but China's national gene pool not only to ecological protection, development, use of the data will have a bigger role, such as deciphering the genetic code, also can be used for accurate medical.

Which, in precision medical aspects, national gene pool started of million cloud health queue project, "from mother pregnancy to child 4 age middle of key points on mother and child of key of genetic information, and key of biological sample and some physiological features for detailed of save, to this established up maternal and child health most strong of mechanical and queue, while on maternal and child health of precision medical provides database of service. "According to the State Executive Director Xu introduced the gene pool, the national gene bank the main aim is to be able to save samples, save data, save the information, but at the same time we are also used to store to promote industrial development, we not only for scientific research, also promotes the development of precision medical, precision agriculture, China.

　　Quest stand combines oxygen bar hinterland and nature

This looks like a vast terraced building, is located in the Shenzhen Dapeng Dapeng Street in Xiasha district area, "Wo Tong Zi" plots, each story building leaning against the natural slope of the Hill building, mountain structure support, and integrated with nature. Architectural design concept of the national gene bank reference Peach Garden, terraces, stone, whose son (ecology, production, life) this concept of integration, is a relatively independent ecological architecture with the outside world. Into a national gene bank, and décor are appropriate and science closer, for example, that paragraph from the Hall stairs leading to the second floor of the Treasury, rising spiral, design is the shape of DNA.

State gene bank in "oxygen bar" on the hinterland, facing the ocean, surrounded on three sides, "stand here, number of PM2.5 concentrations lower than urban areas. "The national gene pool commentator said.

At the national gene bank, have two huge bronze mammoth is very special, "with two national gene bank was asked why mammoths. "Xu explained, mammoth is a vanishing species, 5,000 years ago, is a large mammal, but its cells can be saved in its entirety, because it saves us to resume embryonic," If there is a suitable parent, you can be resurrected mammoth. "This is using the results of gene's life. In the lobby, in addition to showing Monster outside, some herbs, micro-biological stage.

　　Large equipment on hundreds of millions of Yuan

At the national gene bank, after the international front-end equipment in the home to hundreds of millions of Yuan, has already started work.

New Express Reporter, located on the 3 floor is the sequence on the left side of the engine room, stocked with 150 BGI-Seq500 of China's self-developed gene sequencer, and a cost of 20 million dollars of Revolocity Super Sequencer. These devices produce large amounts of data every day, eventually will be available to research institutions and companies around the world released. Sample area on the 5 floor, decorated with the lowest temperature can reach lingxia90sheshidu Chinese-made refrigerators, each refrigerator storing more than 10 samples, "refrigerator main storage is RNA, DNA, and some plasma, store currently has 5.5 million samples, sample sizes are increasing every day, Shenzhen now has 6 sample size. "As far as the narrator says of the area.

　　Will be the platform for popular science education in the future the public can visit

Live online interactive sessions on September 22, after watching live coverage of the national gene bank, netizens wonder says: "I want to see. "How to walk into national gene pool? If close contact with these sophisticated devices? According to press reports, the national gene pool is not only a biological sample resources and biological information data storage, platform, will also be a platform for popular science education. Future will be more of the public entered the national gene bank, and scientific dialogue. "Exactly when visited on our Web site will provide the public, we are the biggest gene pool, science education is also one of our functions. , "Xu said.

　　Establishment of a national gene bank,

　　What can I change?

New Flash: this gene is under what mechanism realizing resource sharing?

BGI Chairman Wang Jian: we are a non-profit, and assumes the State mission of the national gene pool is, of course, free of charge, but some people are paid to do, and we encourage everyone to contribute to the development of human society. The sooner and taking things out of these shares, a total of, the benefits you can get.

New Flash: establishment of national gene bank what promoted the understanding of genome?

Wang Jian: big data can reveal very clear rules, we don't need a lot of hypothesis, data-driven pattern to create a whole new pattern.

Interview: new bulletin reporter Zheng Yanhong

Photo credit: Express Reporter congratulated

Responsible editor: Gao Yuying

Article keywords:
Mammoth national gene bank in Shenzhen

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中国国家基因库运营 五千年前猛犸象也许可以复活|猛犸象|国家基因库|深圳_新闻资讯
国家基因库内的猛犸象雕塑格外引人注目。
馆内展示着各种动物的标本。
深圳国家基因库内部。
数据机房。它的存量假如一个人每天24小时看电影，可看十万年。

　　继美国国家生物技术信息中心（NCBI）、欧洲生物信息研究所（EBI）、日本DNA数据库（DDBJ）之后，全球第四个国家级基因库——位于深圳的国家基因库于昨日正式运营。它是中国首个，也是唯一一个国家基因库，相对于全球另外三个基因库而言，国家基因库样品保存的规模、存储量和可访问的数据量皆是全球最大。在这里，经过对基因的解码到重编，解读到书写，合成与编辑等，已经灭绝的物种或可再复活。未来，这里将是一个科普平台，会有更多公众走入其中，对话科学。

　　规模 储存样本超过1000万份

　　国家基因库的占地面积超过5万平方米，建筑总面积11.6万平方米，已经投入使用的第一期建筑面积4.75万平方米。还将有二期、三期建设。中国拥有的这艘“诺亚方舟”，承载着人类及其他生物的遗传样本和密码。

　　新快报记者了解到，历时五年准备，国家基因库在生物大样本及资源存储、基因测序、数据库建设、基因合成、基因编辑及产业应用等方面，多项指标处于国际领先水平。它是全世界最大的综合性基因库，其中，样本库已储存样本超过1000万份； 数字化平台年产数据5Pb以上；活体库保护和保存世界约三十万种植物、百万种动物、近千万种微生物活体资源。

　　优势 对数据研发利用有更大作为

　　位于深圳大鹏新区的国家基因库是继美国国家生物技术信息中心（NCBI）、欧洲生物信息研究所（EBI）、日本DNA数据库（DDBJ）之后的第四个国家级基因库。前三个基因库更多的是以保存数据为主，但中国的国家基因库不仅仅有利于生态保护，对数据的研发、利用会有更大的作为，比如破译基因密码，还能作用于精准医疗。

　　其中，在精准医疗方面，国家基因库启动的百万云健康队列项目，“从母亲怀孕到小孩4岁中间的关键点对母亲和小孩的关键的遗传信息、关键的生物样本和一些生理特征进行详细的保存，以此建立起母婴健康最强的机械和队列，同时对母婴健康的精准医疗提供数据库的服务。”据国家基因库执行主任徐讯介绍，国家基因库主要的目的就是为了能够存样本、存数据、存信息，但同时我们还要把储存利用到推动产业发展中去，我们不仅面向科研，还面向推动中国精准医学、精准农业的发展。

　　探秘 立于氧吧腹地与自然相融合

　　这个外观仿若巨大梯田的建筑，就位于深圳市大鹏新区大鹏街道下沙片区“禾塘仔”地块，每一层建筑都倚着山体的自然坡度建设，有山体结构的支撑，与自然融为一体。国家基因库的建筑设计理念参考桃花源、梯田、山石、三生（生态、生产、生活）融合的概念 ，是一个与外界相对独立的生态建筑。一走入国家基因库，随处可见的装潢则恰如其分与科学靠拢，比如，那段从大厅通往二楼的库房的楼梯，螺旋状上升，设计的就是一个DNA的形状。

　　国家基因库站在“氧吧”的腹地上，面朝大海，三面环山，“站在这里，PM2.5的浓度要比市区低几个数。”国家基因库讲解员说。

　　在国家基因库内，有两头巨大的古铜色的猛犸象显得很特别，“有人问国家基因库为什么要放着两头猛犸象。”徐讯解释，猛犸象其实是一个消失了的物种，5000年前是大型的哺乳动物，但是它的细胞可以完整地保存，因为这样的保存我们才可以恢复出来胚胎，“如果有合适的母体的话就可以重新复活猛犸象。”而这，正是利用基因合成生命的结果。在大堂，除了展示庞然大物外，一些草本植物、微小生物也登台亮相。

　　高大上设备动辄数亿元

　　在国家基因库内，动辄数亿元的国际前端设备在这里安家后，已经开始运作。

　　新快报记者了解到，位于3楼的左侧是测序机房，这里摆放着中国自主研发的150台BGI-Seq500基因测序仪，以及一台造价2000万美元的Revolocity超级测序仪。这些设备每天产生大量的数据，最终会面向全球的科研机构、企业发布。位于5楼的样品区，摆放着温度最低可以达到零下90摄氏度的中国国产牌冰箱，每台冰箱储存十几个样本，“冰箱主要存储的是RNA、DNA，还有一些血浆，目前存储了有550万个样本，样本量每天都会增加，深圳地区现在增加有6台样本量。”据该区的解说员说。

　　未来将是科普教育平台 公众可参观

　　在9月22日的直播网友互动环节，在观看国家基因库的现场直播后，就有网友惊叹表示：“我也想去看看。”如何走进国家基因库？能否近距离接触这些高精尖的设备？据记者了解，国家基因库不仅是生物样本资源和生物信息数据的储存、利用平台，也将是一个科普教育平台。未来将能有更多的公众走进国家基因库，与科学对话。“等完全建好后，在我们的网站会提供公众参观的方式，我们是最大的基因库，科普教育也是我们其中之一的功能。”徐讯说。

　　成立国家基因库，

　　能改变什么？

　　新快报：这个基因库是按照什么机制实现资源共享的？

　　华大基因董事长汪建：我们是一个公益性、担负着国家使命的国家基因库，当然是免费的，但是有人是付费做的，我们鼓励大家都为人类社会发展做贡献。越早地把这些东西拿出来共享、共为，你就可以得到更大的效益。

　　新快报：国家基因库的成立对基因组的理解会有什么促进作用？

　　汪建：大数据能够很清晰地揭示规律，我们不需要那么多假说，大数据驱动模式会形成一种全新的模式。

　　采写：新快报记者 郑雁虹

　　摄影：新快报记者 祝贺

责任编辑：高玉营

文章关键词：
猛犸象 国家基因库 深圳

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