DNA virus-DNA Vaccine successfully prevented infection of macaques Zhai. vaccine-IT information
United States allergy and infectious disease research papers published in the journal Science, researchers said they developed a new DNA (deoxyribonucleic acid) Zhai vaccines, animal experiments show that Zhai card, this vaccine can stop monkeys infected with the virus. At present, the vaccine has entered human clinical trials to verify its safety and effectiveness for human. Taide·piersen, Director for the Institute of Pathology explained that the vaccine contains a card from Zhai synthetic DNA fragments of the virus, when injected into the body, cells secrete lots of small, village-like virus particles, these particles can stimulate the immune system to produce antibodies response, Zhai card virus infection prevention. "These DNA vaccines have been successful, a few years ago, have used similar techniques to develop candidate vaccines for West Nile virus. ”
In order to verify the potential effectiveness of Zhai cards, DNA vaccines, researchers injected 6 rhesus monkeys with a dose of vaccine containing a single DNA fragments, and the 18 monkeys were injected with a dose of vaccine contains two DNA fragments. Results showed that monkeys treated with single-dose injection of Zhai card are infected with the virus, but their blood virus levels than a control group who did not receive DNA vaccination, proving that the vaccines are in the monkeys ' body produces an antibody reaction and those monkeys treated with double-dose injections, 17 only Zhai card virus infection, this dose sufficient antibody response against infection.
Zhai, the virus can cause microcephaly and other birth defects. It was reported that the village of South America last year during an outbreak of the virus, there are thousands of newborns suffering from congenital microcephaly; as of September 21, United States Southern California village of infections has risen to 43, needed Zhai vaccines to prevent birth defects.
Studies have shown that Zhai card virus cause of neurodevelopmental problems in newborns is, the virus will infect the fetus by the mother and attacked the developing neurons. Another researcher, University of Pittsburgh Medical Center, an infectious disease expert and health safety amaishi·adajia said: "our DNA vaccine produced an immune response in the body of pregnant women, prevent fetal infection Zhai card virus and thereby prevent birth defects. This vaccine is an important innovation village developed vaccines, once humans clinically proven safe and effective, will become the first commercial DNA vaccines. ”
DNA疫苗成功阻止猕猴
感染寨卡
病毒 - DNA.疫苗 - IT资讯
美国过敏和传染病研究所科研人员在《科学》杂志发表论文称，他们开发出全新的DNA（脱氧核糖核酸）寨卡疫苗，动物实验证明，这种疫苗能阻止猴子感染寨卡病毒。目前，该疫苗已经进入人体临床试验阶段，验证其用于人类的安全性和有效性。该研究所病毒病理部门主任泰德·皮尔森解释说，这种疫苗含有一段来自寨卡病毒的合成DNA片段，注射到体内后，细胞会分泌出很多类似寨卡病毒的小粒子，这些粒子能刺激免疫系统产生抗体反应，预防寨卡病毒感染。“这类DNA疫苗有过成功先例，几年前已用类似技术研制出西尼罗病毒的候选疫苗。”
为了验证DNA寨卡疫苗的潜在效力，研究人员给6只猕猴注射了含单个DNA片段的疫苗剂量，并给18只猴子注射了含两个DNA片段的疫苗剂量。结果发现，接受单剂量注射的猴子都感染了寨卡病毒，但它们血液中病毒含量比那些没接受DNA疫苗注射的对照组低，证明疫苗已经在猕猴体内产生了抗体反应；而那些接受双剂量注射的猴子，有17只没有感染寨卡病毒，证明这种剂量足以形成免受感染的抗体反应。
寨卡病毒能够引起小头症等新生儿缺陷。据报道，去年南美洲寨卡病毒暴发期间，有数千新生儿患上了先天性小头症；截至9月21日，美国南加州的寨卡感染病例已升至43人，急需预防出生缺陷的寨卡疫苗。
研究表明，寨卡病毒引起新生儿神经发育缺陷的原因是，病毒会通过母体感染胎儿并攻击其正在发育的神经元。另一位研究人员、匹兹堡大学医学及卫生安全中心的传染病专家阿麦什·阿达加称：“我们的DNA疫苗能在孕妇体内产生免疫反应，阻止胎儿感染寨卡病毒从而避免出生缺陷。这类疫苗是研制寨卡疫苗的重要创新，一旦人体临床证明安全有效，将成为第一个商业化DNA疫苗。”