Experts: baking soda "starve" argument is misleading is not responsible for | bicarbonate | cancer cells of cancer cells _ news
On September 24, a published by Xinhua, the breakthrough medical progress messages! Cancer cells are Chinese doctors with baking soda "hungry" dead were widely reproduced, today in the high incidence of cancer, the news is enough to set off your circle of friends. People are attracted to its vivid title, and for the so-called cheap soda has conquered the powerful contrast to conquer the enemy of human life and driving performance of baking soda cure cancer cancer prevention "keeping secrets".
Whether that is the case? How does baking soda into something presentable, became known as the King of the low cost of cancer-Buster? Is baking soda cancer treatment known as the main dish or a chili? Whether to starve the cancer cells spread this long scientific rigour? Health secret of the spread of science make sense?
Carnival in contrast with the public, is the medical profession's calm, both from the results of the study team of Zhejiang University, is an anti-cancer medicine experts on the front lines, there is a similar "plus": this is just the initial results of an academic study from clinical application is premature.
This conclusion is not stimulating enough eyeballs, but perhaps closer to the medicine itself.
"Starving to death" is not precise
This was called by the media "the baking soda to starve the cancer cells" therapy called called "TILA-TACE therapy (in targeted tumor lactate anion and hydrogen ions of arterial infusion chemoembolization)" Hu flood, Institute of Oncology of Zhejiang University professors and Zhejiang, two Interventional Science Professor Chao ming team proceeds, for the treatment of primary hepatocellular carcinoma of middle and advanced.
The study was objective, and published in prestigious journals on the eLife.
"' Baking soda to starve the cancer cells ' by many media on the title, this is science, not rigorous, even misleading. "In interview with the science and technology daily journalist, Cancer Hospital of gastrointestinal medical oncology expert at Peking University, Professor Director Zhang Xiaodong said," because the intravenous administration of sodium bicarbonate baking soda is obviously not the same as we eat, this headline on the patients, the people are extremely irresponsible! ”
Many liver cancer patients are exposed to "embolization" this treatment, the news said, "with baking soda to starve cancer" research, is to jointly "embolization" do together. "Conventional therapy of interventional therapy of advanced hepatocellular carcinoma. "Zhang describes, generally speaking, the method is inserted a catheter from the vessel, put drugs into the liver lesions. Embolization can be one of the drugs of choice, can block the blood supply, focal necrosis.
Zhang explained that the TILA-TACE is based on the Interventional treatment of injection of baking soda, hydrogen ion removed inside the cancer cell decomposition of lactic acid, cancer cells are less glucose, thus speeding up the death of cancer cells. Is not a general concept of "starving to death", much less prevent cancer patients to eat something nutritious. "New treatments not sodium bicarbonate alone, mainly the role of chemotherapy drugs, is a comprehensive treatment. ”
40 cases clinical trials are only a small sample
Effect of new research methods were a lot of people are concerned about the problem.
But China's prominent Hepatology experts, Cancer Center of Sun Yat-sen University Hepatology Director, Sun Yat-sen University, Director of the Institute of liver cancer Professor Chen Minshan said, speaking from the medical point of view, this is just a small sample of clinical research, from the extensive clinical use and there is a big gap.
Chen Minshan believes that the number of non-randomized study is not much, add up to only 40 cases. Paper references in the two papers, one published in the journal of Pathology, rather than recognized cancer research magazine; another was a review, not works. In addition, the researchers have not published the results of animal experiments. "This is an example of a small number of early-stage clinical trials, in a few people to see the effect, but need to do more large-scale experiments in the late. ”
Zhang also said that treatment only for single foci of small liver cancer, news reports said that studies reaction rates are 100% effective, but this does not mean that it can apply to all in the treatment of patients with liver cancer, the current norms in the treatment of small liver cancer are surgery and radiofrequency treatment is the preferred, hospitals such as through strict clinical research ethics committee approval and informed consent.
Zhang believes that new research methods in the original improvements have been made on the basis of improved efficacy may be good or bad, this large, randomized clinical studies need to be verified. "From the sample sizes, dozens of cases too small, may be affected by interference of human factors in the sample selection, bias. ”
In addition, the research team used a single Center trials only, yet multicenter clinical trials. Multicenter clinical trials are conducted by several researchers in the hospital according to the same scheme, test their data much more persuasive than single centre trials. Zhang pointed out that judging from media reports, the research team has not conducted a randomized controlled trial. So-called randomised, is also eligible in all patients and treated in the same way, the only difference is that one group used the baking soda, another group is not, and then observe the difference. "As the research team said, also need to be more strict, large scale randomized controlled clinical trials, to determine its efficacy. ”
In fact, any new drug or a new method of treatment requires rigorous, standardized certification process, want to get clinic promotion, must meet the phase III randomized clinical studies, clinical study on 40 cases of mere exploration study. "Liver cancer treatment at the international level and domestically there is a general consensus and guidelines, any treatment within the ambit of this principle. "Zhang said.
And it is only effective against certain cancers, is not a panacea. Some of the media reports exaggerated the effects of it, is not rigorous.
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Treatment of hepatocellular carcinoma which weapon
"Current best is surgical resection in the treatment of liver cancer, five-year survival rate in patients after surgical excision is also good. "But Zhang also said, not every tumor of liver cancer patients, are suitable surgical resection. For patients with tumor cannot be used, such as in patients with advanced liver cancer patients, clinical treatment with TACE in General. TACE treatment according to the number of each patient's condition needs to be determined.
TACE alone can cure liver cancer although the clinical example of not much, but you can extend the survival of patients, or that some patients ' tumors to shrink, then consider surgery, or the ablation. Zhang stressed that the liver cancer treatment is multidisciplinary problems require multiple disciplines dominated by surgical treatment combined with, not a single method can be easily cured. Even if new Interventional treatments are effective, also belongs to local palliative therapy, and the most difficult to treat liver cancer, or is the transfer and proliferation of cancer cells, which require systemic whole treatment strategies.
Now that can cure cancer, that this approach can put pancreatic cancer? Gastric cancer? Colon cancer? The answer is no, this study addresses the liver cancer, tumors in other parts of the study area. Interventional treatment in itself, is not suitable for all cancer, such as brain tumor, embolization can lead to serious complications. But if the study proved effective for liver cancer does, in principle, possible cancer ...
Physical fitness can adjust the Ph: anti-tumor
NET drank more than 10 dollars of soda can in combating cancer, Zhang Xiaodong explicitly denied: "soda and baking soda are two of medical concepts. Soda to neutralize stomach acid, equivalent to drinking soda in the summer, but for cancer treatment, makes no sense. ”
Deliberately say alkaline environment to control tumor growth and even divided into acidic or alkaline foods, is highly unscientific.
Zhang believes that drinking soda cancer, there is no theoretical and experimental basis. "Human environment pH value within the normal range of 7.35-7.45, through the typical diet is hard to change the body's acid-base environment. ”
Require special attention is that soda is not universally appropriate. Gastric acid secretion is less, drank sodas can aggravate achlorhydria; hypertensive population too much drinking, leads to increased sodium intake in human body, contrary to these measures and treatment of high blood pressure; healthy people also should not be a lot of drinking, otherwise easily lead to excessive levels of sodium in the diet.
Source: Science Daily
Responsible editor: Kun Qu SN117
Article keywords:Baking soda cancer cells
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专家：小苏打“饿死”癌细胞说法是误导 不负责|小苏打|癌细胞_新闻资讯
9月24日，一则由新华社发布的医学进展消息《重大突破！癌细胞竟被中国医生用小苏打“饿”死了》被广泛转载，在癌症高发的今天，这条消息足以引爆朋友圈。人们为其生动形象的标题所吸引，并为所谓廉价的小苏打就具备攻克人类生命之敌能力的强大反差征服，并推演出小苏打就能治癌防癌这样的“养生秘方”。
事实是否果真如此？小苏打究竟如何走进大雅之堂，成为被称为众病之王的癌症的低成本克星？小苏打究竟是癌症治疗中所谓的主菜还是辣椒面？饿死癌细胞这种久已流传的说法是否科学严谨？随之流传的养生秘方有科学道理吗？
与民众的狂欢形成对比的，是医学界的冷静，无论从该项研究成果的浙江大学团队，还是抗癌一线的医学专家们，都有着一个类似的“补充”：这仅仅是一个学术研究的初期结果，距离临床应用尚早。
这个结论不够刺激眼球，但也许更加接近医学本身。
“饿死”的说法不严谨
这种被媒体称为“小苏打饿死癌细胞”的疗法本名叫做“TILA-TACE疗法（靶向肿瘤内乳酸阴离子和氢离子的动脉插管化疗栓塞术）”，是浙江大学肿瘤研究所胡汛教授和浙二放射介入科晁明教授团队研发所得，用于原发性肝细胞肝癌的中晚期治疗。
这则研究是客观存在的，并且发表在著名期刊《eLife》上。
“‘小苏打饿死癌细胞’被多家媒体提上标题，这种说法不科学、不严谨，甚至有误导作用。”在接受科技日报记者采访时，北京大学肿瘤医院消化道肿瘤内科专家，主任医师张晓东教授这样指出，“因为静脉注射用的碳酸氢钠和我们吃的小苏打显然是不一样的，这样的标题党对患者、对百姓都极其不负责！”
很多肝癌患者都接触过“介入栓塞”这种治疗，新闻里说的“用小苏打饿死肿瘤”的研究，就是联合“介入栓塞”一起做的。“介入治疗是中晚期肝癌的常规疗法。”张晓东介绍，通俗地讲，该方法是从血管中插入一根导管，把药物打入肝脏的病灶中。栓塞剂是可以选用的药物之一，能阻断血液供应，让病灶坏死。
张晓东解释说，TILA-TACE是在介入治疗的基础上注射小苏打水，去除癌细胞里面乳酸分解出的氢离子，使癌细胞更少地利用葡萄糖，从而加速癌细胞死亡。并非一般概念上的“饿死”，更不是防止癌症患者吃有营养的东西。“新的治疗方法不是单靠碳酸氢钠，主要还是化疗药的作用，是一个综合的治疗。”
40例临床实验只是小样本
新研究方法的疗效是很多人都关心的问题。
但中国著名肝胆科专家、中山大学肿瘤防治中心肝胆科主任、中山大学肝癌研究所所长陈敏山教授却表示，从医学的角度上讲，这个研究仅仅是一个小样本的临床研究，离大面积的临床使用还是有很大的差距。
陈敏山认为，这项研究的非随机对照研究例数不多，加起来仅40例。论文主要参考的两篇论文里，一篇发表在病理学杂志，而不是公认的癌症研究杂志；另一篇是一个综述，而不是论著。此外，研究者们并没有公布动物实验的结果。“这是一个例数较少的早期临床试验，在少数人身上看到了效果，但需要后期做更多大规模的实验。”
张晓东也表示，治疗只针对单灶的小肝癌，新闻报道中说研究中反应率是100%有效，但这并不意味着能适用到所有的肝癌病人治疗中去，目前小肝癌规范治疗还是以手术和射频治疗为首选，各个医院如有临床研究也要通过严格的伦理委员会审批和患者知情同意。
张晓东认为，新的研究方法在原来的基础上做了改进，改进后疗效可能会好，也可能不好，这需要大规模、随机分组的临床研究进行验证。“从样本量来看，几十例的样本量太小，在样本选择上可能受到人为因素的干扰，产生偏差。”
另外，研究团队只进行了单中心试验，还没有进行多中心临床试验。多中心临床试验是由多个医院的研究者按同一方案进行的试验，其数据的说服力远高于单中心试验。张晓东指出，从媒体报道来看，研究团队并没有进行随机对照试验。所谓随机对照，就是选择同样符合条件的两组病人并使用同样的方法治疗，唯一的区别在于一组使用了小苏打，另一组没有，然后观察其差别。“正如研究团队所说，还需要更严格的、大样本的随机对照临床试验，来鉴定其临床疗效。”
事实上，任何一个新药或一个新的治疗方法需要有严谨、规范的认证过程，想要拿到临床上去推广，必须达到III期随机对照临床研究才行，40例的临床研究仅仅是探索研究而已。“其实肝癌治疗在国际上和国内都是有共识和指南的，任何治疗不能超越这个原则。”张晓东如是说。
而且它只对一些特定的癌症有效，不是万能的。部分媒体的报道夸大了它的治疗效果，很不严谨。
链 接
治疗肝癌有哪些利器
“目前肝癌治疗效果最好的还是手术切除，手术切除后患者五年生存率也不错。”但张晓东也表示，并不是每一个肝癌患者的肿瘤，都是适用手术切除。对于不能用手术切除肿瘤的患者，如中晚期的肝癌患者，目前临床上普遍是用TACE治疗。TACE治疗的次数需要根据每一个病人的病情需要确定。
尽管目前临床上TACE能够单独治好肝癌的例子不多，但可以延长患者的生存期，或者让有些患者的肿瘤缩小，再考虑手术切除，或是联合消融治疗。张晓东强调，肝癌治疗是多学科问题，需要以外科为主导的多个学科与治疗方法配合，绝不是单一的方法就能轻易治好。即使新的介入治疗手段很有效，也属于姑息性局部治疗方法，而肝癌最难治疗的，还是癌细胞的转移和扩散，这就需要全身整体考虑治疗策略。
既然能治肝癌，那这种方法能不能治胰腺癌？胃癌？肠癌？答案是否定的，目前这项研究只针对肝癌，其他部位的肿瘤并不在研究范围内。而且本身介入栓塞这种治疗方法，也不是适合所有肿瘤的，比如脑部肿瘤，做栓塞就会带来严重的并发症。但如果最终证实这项研究对肝癌确实有效，那么从原理上来说，可能对其他肿瘤有借鉴意义。
调整了酸碱体质就能抗肿瘤吗
针对网传的喝十几块钱的苏打水就能抗治肿瘤的说法，张晓东明确予以否认：“喝苏打水和医疗上的小苏打是两种概念。喝苏打水可以中和胃酸，相当于夏天喝汽水，但对于治疗肿瘤，没有任何意义。”
刻意说碱性环境有利于控制肿瘤生长，甚至把食物划分为酸性或碱性，都是极不科学的。
张晓东认为，喝苏打水防癌，目前没有任何理论和实验依据。“人体内环境pH值正常范围在7.35—7.45之间，通过一般的饮食很难改变身体的酸碱环境。”
需要特别注意的是，苏打水并非人人皆宜。胃酸分泌少者，喝苏打水会加重胃酸缺乏；高血压人群过多饮用，会导致人体钠的摄入量增加，这与治疗高血压的措施相悖；健康人同样不宜长期大量喝，否则容易引起饮食中的钠含量超标。
来源：科技日报
责任编辑：瞿崑 SN117
文章关键词： 小苏打 癌细胞
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