Chinese University on genetically engineered cows to: resistance to tuberculosis
Foreign media said Chinese researchers first genetically engineered cows genetically modified, making it resistant to tuberculosis. Bovine tuberculosis in most developed countries remain well contained, but in developing countries, the disease is often fatal, and can spread to humans and other animals.
USA Newsweek website local time on February 1 was published, entitled the Chinese scientists bred cows with anti-TB reported from China's Northwest Sci-Tech University researchers using a technique known CRISPR, 20 cows implanted a gene associated with anti-TB, 11 cows lived for 3 months. These genetically engineered cows have a better ability to resist TB. After genetically, nor do they exhibit any unexpected symptoms. Describe the findings in a paper published in the January 31 United Kingdom the journal Genome Biology.
CRISPR is a development in the past years of gene editing tools. Compared with the prior art, it can quickly insert genes in specific locations in the genome of an organism, and low cost. Researchers using this technology to transform many organisms, including transformation in the laboratory of human embryos and modified mice cause Duchenne muscular dystrophy gene.
In this study, the scientists used a new technique of CRISPR, ideal location to insert genes into cow genome fragment of a DNA chain on a single gene. CRISPR technique involving the use of molecular "scissors" to cut the two strands of DNA. Host defense laboratory researchers said suke·Sai·delawan, the advantages of this new technology is that it may be more secure. The lab under the United States National Institute of Allergy and infectious diseases.
Delavan said: "I think this is a great study, proved a potentially safer methods for genetic modification is feasible. "But in his view, must have further studies to prove the results of security.
He added that improve resistance to infection may significantly reduce the overuse of antibiotics in livestock, which has been a serious problem.
Host defense laboratory and Hali·malaike, head of the National Institute of Allergy and infectious diseases, said breeding cows in milk helps to reduce the spread of tuberculosis, which is a major health problem in developing countries. He added, the United States and much of the West area widely used method of pasteurization, to a large extent "Elimination of TB risk from milk, although the raw milk and cheese passion ignited again this risk."
Selected genes male Corporation of the United States Vice President Chake·satele said that researchers are already without genetically engineered cows found the inserted gene. He said researchers use CRISPR technology changes may also occur during traditional farming, but uses genetic modification technology faster and more targeted.
This genetically modified cows in the United States approved, must be approved by the food and drug administration review. Sadtler adds that for now its cost is too high.
(Editors: Liu Longlong UN827)
2017-02-04 12:18:42
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中国一大学对奶牛进行基因改造：可抵抗结核病
外媒称，中国研究人员首次利用基因工程对奶牛进行基因改造，使其能够抵抗结核病。牛结核病在大多数发达国家受到良好控制，但在发展中国家，这种疾病往往是致命的，并且会传播给人类和其他动物。
美国《新闻周刊》网站当地时间2月1日发表题为《中国科学家培育出抗结核病的奶牛》的报道称，来自中国西北农林科技大学的研究人员利用一种名为CRISPR的技术，对20头奶牛植入了一种与抗结核病相关的基因，其中11头牛活过了3个月。这些进行过基因改造的奶牛具有更好的抵抗结核病的能力。经过基因改造后，它们也没有表现出任何意料之外的症状。描述这些发现的一篇论文发表在1月31日的英国《基因组生物学》杂志上。
CRISPR是一种在过去几年里开发的基因编辑工具。和之前的技术相比，它可以快速将基因插入有机体基因组中的特定位置，并且成本较低。研究人员利用这种技术来改造许多有机体，包括在实验室里改造人类胚胎和修正老鼠体内引发杜氏肌营养不良症的基因。
在这次的研究中，科学家们使用一种新版的CRISPR技术，将基因插入到奶牛基因组理想位置上一条DNA链的单个基因片段中。此前的CRISPR技术涉及使用分子“剪刀”来剪开DNA的两条链。宿主防御实验室的研究人员苏克·塞·德拉万表示，这种新技术的优势是它可能更为安全。该实验室隶属美国国家过敏症和传染病研究所。
德拉万说：“我认为这是一项非常棒的研究，证明了通过一种潜在更安全的方法来进行基因改造是可行的。”不过他认为，必须有进一步的研究来证明其结果的安全性。
他补充说，提高动物对感染的抵抗力可以在牲畜中大幅减少抗生素的过度使用，后者已经是一个严重问题。
宿主防御实验室及国家过敏症和传染病研究所的负责人哈里·马莱克表示，培育这样的奶牛有助于减少牛奶中结核菌的传播，这是发展中国家的一个重大健康问题。他补充道，美国和西方大部分地区广泛使用巴氏灭菌法，在很大程度上“消除了来自牛奶的结核病风险，尽管人们对生牛奶和奶酪的热情再度引燃了这种风险”。
美国精选公畜公司的基因项目副总裁查克·萨特勒说，研究人员已经在一些未经基因改造的牛身上发现了这种插入的基因。他表示，研究人员使用CRISPR技术作出的改变也可能在传统养殖过程中出现，只不过使用基因改造技术能够更快、更有针对性。
这种经过基因改造的奶牛要在美国获得批准，必须通过美国食品和药物管理局的审查。萨特勒补充说，就目前而言其成本太高了。
(责任编辑：柳龙龙 UN827)
2017-02-04 12:18:42
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